In the 1990s and 2000s, the roles of antibodies in the condition became clearer. Diagnostic criteria were proposed in the 1960s and refined two decades later. Variants of the condition, such as stiff-limb syndrome which primarily affects a specific limb, are often seen. A small minority of patients have the paraneoplastic variety of the condition. SPS occurs in about one in a million people and is most commonly found in middle-aged people. Chronic pain, impaired mobility, and lumbar hyperlordosis are common symptoms. The stiffness primarily affects the truncal muscles and is superimposed by spasms, resulting in postural deformities. Stiff-person syndrome ( SPS), also known as stiff-man syndrome, is a rare neurologic disorder of unclear cause characterized by progressive muscular rigidity and stiffness. Muscular rigidity and trigger-induced painful muscle spasms
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